[ Prev | Top | Next ]

Publication Date - 12/3/1999

11. NIH/NCI/NICHD/NIDDK/NIA & NIEHS - Stages of Breast Development: Normal to Metastatic Disease

The National Cancer Institute (NCI), the National Institute of Child Health and Human Development (NICHD), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Institute of Aging (NIA), and the National Institute of Environmental Health Sciences (NIEHS) invite investigator-initiated research grant applications to study the molecular, cellular, endocrine, and other physiological influences on the development and maturation of the normal mammary gland and alterations involved in early malignant and metastatic breast cancer. Multi-disciplinary collaborations are encouraged.

Appropriate studies include, but are not limited to, the following:

• documenting the role of dynamic hormonal influences and determining the role of cell growth, apoptosis, and differentiation in mammary gland maturation;
• integrating knowledge of cell signaling in breast tissue with whole organ biology;
• developing models of breast differentiation;
• studies focusing on the characteristics of breast tumor physiology, particularly in relation to metastasis.

The support mechanism for this program announcement (PA) will be the NIH research project grant (RO1). The total project period for a response to this PA may not exceed five years. This PA will expire in two years from the last receipt date in the calendar year, October 2002.

Applications are due at the NIH Center for Scientific Review on or before FEBRUARY 1, JUNE 1, or OCTOBER 1, 2000.